The mechanisms of gonococcal transmission and colonization of the genital tract epithelium are outlined, and host-pathogen interactions that drive inflammation, immune evasion, and immune suppression are examined.
M. Girgis, M. Christodoulides· Virulence· 0 citations
Neisseria gonorrhoeae causes ∼82.4 million infections annually and is rapidly approaching an untreatable status. The pathogen has developed resistance to every antibiotic class introduced since the sulfonamide era. Ceftriaxone, the last WHO- and CDC-recommended empirical therapy, is now compromised by high-level resi...
Ravi Kant, S. Mazumdar, Ananya Mahajan et al.· ACS Infectious Diseases· 0 citations
A stability-centric computational discovery pipeline to identify and characterize novel antimicrobial peptides with potent and selective bactericidal activity against ESKAPE pathogens and to validate the lead candidates through experimental in vitro assays provided a generally applicable strategy for accelerating the d...
H. S. Mahrosh, M. Christodoulides, A. Jamil· Probiotics and Antimicrobial...· 0 citations
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