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Author

M. Campone

2 papers indexed here

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Open access Sep 2026

Safety and efficacy of ceralasertib, an ATR kinase inhibitor, combined with olaparib: dose escalation in advanced solid tumours and dose expansion in advanced breast cancer.

BACKGROUND Ceralasertib, an ATR inhibitor, is known to exacerbate replication stress induced by the PARP inhibitor (PARPi) olaparib, with the combination having the potential to overcome PARPi resistance in the clinic. This modular Phase 1 study evaluated the combination in advanced solid tumours, including breast canc...

Juanita S. Lopez, Seock-Ah Im, S. Postel-Vinay et al. · 0 citations
Open access Sep 2026

Exploring tumorigenesis as a process of phenotypic state-space exploration and selective funneling

Abstract Tumorigenesis is widely studied within evolutionary frameworks, yet integrating genetic, non-genetic, spatial, and collective tumor-level dynamics into a unified description remains challenging. Here, we propose that tumorigenesis can be analyzed as a process in which tumors generate, explore, and filter pheno...

F. Thomas, M. L. Wong, Robert M. Hazen et al. · 0 citations

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