BACKGROUND
Ceralasertib, an ATR inhibitor, is known to exacerbate replication stress induced by the PARP inhibitor (PARPi) olaparib, with the combination having the potential to overcome PARPi resistance in the clinic. This modular Phase 1 study evaluated the combination in advanced solid tumours, including breast canc...
Juanita S. Lopez, Seock-Ah Im, S. Postel-Vinay et al.· British Journal of Cancer· 0 citations
Abstract Tumorigenesis is widely studied within evolutionary frameworks, yet integrating genetic, non-genetic, spatial, and collective tumor-level dynamics into a unified description remains challenging. Here, we propose that tumorigenesis can be analyzed as a process in which tumors generate, explore, and filter pheno...
F. Thomas, M. L. Wong, Robert M. Hazen et al.· Evolution, Medicine and Publ...· 0 citations
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