M. Calcutt

Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut.

The Gram-positive opportunistic pathogen Clostridioides difficile colonizes the gut by adapting to an array of threats from the host and the microbiome. A potential threat from the microbiome is the antimicrobial peptide bacitracin, which is produced by the commensal Bacillus licheniformis and prevents dephosphorylatio...