Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for advanced Parkinson's disease (PD), primarily targeting motor complications refractory to pharmacological treatment. However, its long-term impact on functional autonomy and quality of life (QoL) remains debated. Objec...
Laura Culicetto, M. C. De Cola, F. Vitiello et al.· Journal of Parkinson's Disea...· 0 citations
Introduction
One of the M-Brain project's aims is to identify biomarkers that can distinguish between healthy and pathological ageing. The choice of classifier can have a significant impact on predictive performance due to the challenges posed by limited sample size, class imbalance and heterogeneous features. Using d...
M. C. De Cola, F. Vitiello, Chiara Scarfì et al.· Epidemiology Biostatistics a...· 0 citations
It is suggested that glial lncRNAs are crucial regulators of neuroinflammation in cognitive disorders, and their ability to modulate pathways such as the NLRP3 inflammasome makes them promising diagnostic biomarkers and therapeutic targets.
Chiara Malatino, Ivana Raffaele, Angelo Quartarone et al.· Frontiers in Aging Neuroscie...· 0 citations
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