Open access
Sep 2026
Tissue resident CD4+ memory T-cells mark response to immune checkpoint inhibition in high-grade glioma
Background Immune checkpoint inhibitors (ICI) are efficacious in many solid tumors, but response in glioma is restricted to a small subgroup. The determinants of response and resistance to ICI remain poorly understood. Methods Here we exploit a syngeneic hypermutated high-grade glioma model with dichotomous response to...
Verena Turco, Chin-Leng Tan, D. Agardy et al.
· bioRxiv · 0 citations