Open access
Oct 2026
Stable molecular signatures and age-related microstructural remodeling of the Purkinje network in sheep and human hearts
The ventricular Purkinje network is a recognized trigger and substrate of malignant ventricular arrhythmias, particularly with ageing, yet remains poorly characterized in large mammals due to limited molecular specificity and difficulty resolving its microstructure. Rodent-derived markers lack reproducibility in...
R. Walton, S. C. Guitoger, J. Leury et al.
· European Heart Journal · 0 citations