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Open access Aug 2026

Body mass index outperforms the Rotterdam criteria in defining phenotypic heterogeneity in polycystic ovary syndrome: a multicenter study from the Italian PCOS registry (PCOSOUTCOME.net)

Polycystic ovary syndrome (PCOS) is a common and highly heterogeneous endocrine–metabolic disorder. The Rotterdam criteria identify four diagnostic phenotypes; however, it remains unclear whether these phenotypes or body mass index (BMI) better predict metabolic risk. The PCOSOUTCOME.net registry collects data from mul...

A. Gambineri, S. Federici, E. Maseroli et al. · 0 citations
Open access Aug 2026

EP1347 - ECE_3043 - Phenotype of Polycystic Ovary Syndrome in women with and without obesity: comparison of clinical, hormonal, metabolic and sexual features

Obesity and Polycystic Ovary Syndrome (PCOS) share key pathophysiological mechanisms, including insulin resistance, hyperandrogenism and hypothalamic-pituitary-ovarian axis dysfunction. In literature, it is debated whether gonadal alterations in PCOS with and without obesity arise from distinct pathophysiological...

C. Manzini, Elisa Delle Donne, Emma Dorato et al. · 0 citations
Open access Aug 2026

P501 - LBA_ECE_1260 - Androgen sensitivity and hypogonadotropic hypogonadism correlate differently and independently with cardiovascular risk in severe obesity

A higher prevalence of increased androgen sensitivity in patients with severe obesity compared with the general population is reported for the first time, suggesting the involvement of distinct pathogenic mechanisms.

B. Cangiano, Alessandro Chilà, Ilaria Gentile et al. · 0 citations

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