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M. Boffa

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Open access Sep 2026

Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis

Introduction Ubiquitination is a major regulatory process that is often dysregulated in carcinogenesis. The C-terminal to LisH (CTLH) complex is a multi-subunit E3 ubiquitin ligase that has been shown to exert tumor-promoting and tumor-suppressing functions. Its core scaffolding subunit, RanBP9, has been implicated in...

Brianna C Gonga-Cavé, Gabriel Onea, Xu Wang et al. · 0 citations
Review Aug 2026

Lipoprotein(a): a unique lipoprotein at the crossroads of atherosclerosis and thrombosis.

PURPOSE OF REVIEW Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are a causal and independent risk factor for atherosclerotic cardiovascular disease and an emerging therapeutic target. However, despite Lp(a) being on the cusp of widespread clinical consideration, fundamental questions regarding the pathophysi...

M. Boffa, M. Koschinsky · 0 citations

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