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Open access Aug 2026

Morphine-induced μ-opioid receptor isoform MOR-1X amplifies dependence-related signaling

Clinically used opioids, such as morphine, primarily act through the μ-opioid receptor (MOR), encoded by the OPRM1 gene, which undergoes extensive alternative splicing. More than 20 OPRM1 isoforms have been identified, yet functional characterization has largely focused on the canonical MOR-1 variant. With the emergenc...

Michael Swingler, M. Donadoni, Senem Cakir et al. · 0 citations

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