Author

M. Biagioli

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Open access Sep 2026

Primary cilia as a molecular convergence hub linking neurodevelopment and autism spectrum disorder

The primary cilium, a highly conserved microtubule-based organelle, orchestrates a broad repertoire of signal transduction cascades required for embryonic development, tissue homeostasis and cellular communication. Disruption of ciliary structure or function results in a heterogeneous group of multisystem disorders kno...

Arianna Boscato, Lorenzo Milesi, M. Biagioli et al. · Frontiers in Cellular Neuros... · 0 citations

Open access Aug 2026

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Abstract Understanding the molecular mechanisms driving selective neuronal vulnerability to different neurodegenerative disorders remains a crucial, unsolved question. Here, we explored the case of Huntington's disease (HD), where the striatum and, specifically, dopamine receptor 1 (D1R) and dopamine receptor 2 (D2R) m...

G. Bergonzoni, Miguel Pellegrini, A. Savino et al. · Brain Pathology · 0 citations

Open access Jul 2026

Mutant Huntingtin disrupts neurogenic and astroglial programs via the EZH2-Let-7g-LIN28 axis with rescue by epigenetic modulators.

It is shown that neurogenesis is disrupted at multiple stages of lineage progression in both rodent and human neural stem cell models of Huntington's disease, and a panel of clinically relevant epigenetic compounds hold promise for stage-spanning therapeutic strategies capable of modifying disease trajectory.

Jessica Rosati, A. Casamassa, G. Ruotolo et al. · Cell Death and Differentiati... · 0 citations