Author

M. Bakun

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Open access Oct 2026

Characterization of Kluyveromyces marxianus Extracellular Vesicles as a New Potential Delivery System for Biologically Active Compounds

Extracellular vesicles (EVs) released by probiotic microorganisms may be involved in intercellular communication via transferring their cargo to other cells. Hence, there is growing interest in their application as a drug delivery system. This article presents studies on EVs secreted by three strains of Kluyveromyces m...

M. Rogalska, Katarzyna Kmita, A. Wrońska et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Findings identify CDK8 as a transcriptional node of LSC-associated programs and provide a mechanistic rationale for combined CDK8-BET inhibition in molecularly defined AML subsets, which will require validation in functional LSC assays and primary specimens.

M. Statkiewicz, I. Rumieńczyk, U. Pakulska et al. · Cells · 0 citations

Open access Aug 2026

TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity

Using a combination of biochemical assays, structural modeling and molecular dynamics, it is shown that TTC33 directly recruits WDR61 and PHF5A to assemble into a trimeric core complex (TANC), which then forms distinct interactions with either UNG1/2 or SF3B–CCDC97.

R. Tomecki, Małgorzata Drabko, Małgorzata Siek et al. · Nature Communications · 0 citations