Author

M. Atkins

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Open access Sep 2026

70 Lymphocyte Hsp70 is a Novel Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

A scRNA-seq atlas of tumors from metastatic RCC found a novel factor, Hsp70, that in lymphocytes strongly predicts response and greatly extended PFS after ICI, indicating that Hsp70 expression in lymphocytes predicts response to ICI across timepoints and cohorts.

Ethan C. Burns, S. Kashima, Rishabh Rout et al. · The Oncologist · 0 citations

Review Sep 2026

Final results and predictive biomarkers of response and long-term outcomes with first-line pembrolizumab monotherapy in advanced renal cell carcinoma in the phase II KEYNOTE-427 study.

These results show that pembrolizumab is a highly active agent in ccRCC and nccRCC and insights from the comprehensive analysis of RCC tumor molecular components and ctDNA may facilitate progress toward effective, biomarker-driven precision treatment in advanced RCC.

D. McDermott, S. Signoretti, J.-L. Lee et al. · Annals of Oncology · 0 citations

Jul 2026

Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.

Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al. · Nature · 2 citations