M. Alghamdi

RASSF2 Under the Computational Microscope: Prediction of Destabilizing Missense Variants

Background: RASSF2 is a tumor suppressor gene involved in multiple cancers such as colorectal and lung cancer. Different studies have focused on promoter hypermethylation as the main inactivation pathway of this gene, which leads to cancer proliferation and metastasis. Here, using a comprehensive in silico pipeline, we...