M. Addo

Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research

ABSTRACT Monkeypox virus (MPXV) is a rodent-borne orthopoxvirus causing mpox disease upon zoonotic transmission to humans. Recent global outbreaks have raised awareness and highlighted the need for basic and translational research. However, research is hampered by the classification of MPXV as a Risk Group 3 pathogen....

Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial

ABSTRACT The rapid development of effective COVID-19 vaccines was enabled by the parallel assessment of multiple candidates early in the pandemic, including candidates based on the Modified Vaccinia virus Ankara (MVA) vector platform. This Phase 1 trial (NCT04569383) evaluated the MVA-based vaccine candidate MVA-SARS-2...

VSV-EBOV vaccination induces cross-reactive T-cell responses against Bundibugyo virus in humans