Author

M. Abdelsayed

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Open access Oct 2026

The ARumenamide AR-788 suppresses the transient outward current in human iPSC-derived right-ventricular Brugada cardioids

Brugada syndrome (BrS) is an inherited arrhythmia disorder with limited drug therapy, quinidine being the principal agent. Loss-of-function variants in SCN5A reduce the cardiac sodium current (INa), but the arrhythmogenic imbalance also depends on the transient outward potassium current (Ito). Here we generated human i...

Y. Guéret, A. Girardeau, S. Godin et al. · medRxiv · 0 citations

Open access Jul 2026

FDA-Approved Drug Repurposing as p53 Mutants Rescue Candidates Using Structure-Based Virtual Screening and Molecular Simulations

This study presents a structure-based virtual screening and molecular dynamics approach to nominate FDA-approved drugs as candidate stabilizers of mutant p53 for downstream experimental validation and nominates DB09280 as a promising candidate structural stabilizer of mutant p53 worthy of experimental follow-up.

M. Abdelsayed, Y. Boulaamane · International Journal of Mol... · 0 citations

Open access Aug 2026

QSAR-Guided Virtual Screening and Molecular Dynamics Reveal Olaparib as a Repurposing Lead Against α-Synuclein Aggregation

These findings identify Olaparib as a novel high-affinity repurposing lead, while Paliperidone and Risperidone are reported as chemically informative secondary NAC–groove binders rather than proposed antiparkinsonian therapeutics, given that their dopamine D2-antagonist pharmacology is clinically associated with drug-i...

M. Abdelsayed, Y. Boulaamane · International Journal of Mol... · 0 citations