Assay-Level Modeling and External Validation of Antibody Developability Using Physicochemical Descriptors and Sequence Embeddings
Antibody developability is inherently multidimensional, involving thermal stability, aggregation and hydrophobicity, nonspecific interactions, and expression-related manufacturability. Instead of treating developability as a single composite label, we investigated assay-level modeling using GDPa1 as a benchmark data...