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Lynn A. Spruce

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Open access Oct 2026

Multi-omic profiling defines subtype-specific extracellular vesicle signatures in early human pregnancy.

Early human pregnancy (11-15 weeks) is a critical period when placental dysfunction begins but remains clinically undetectable, preventing early intervention for pregnancy complications. This highlights a pressing need for circulating biomarkers that can signal the onset of a complication. Circulating extracellular ves...

Kobe A. Abney, Taylor Hollingsworth, Alexandra Schneider et al. · 0 citations
Open access Sep 2026

Procoagulant effects of extracellular vesicles in patients with livedo reticularis

Background Extracellular vesicles (EVs) are lipid-delimited particles that mediate intercellular communication and have been implicated in both autoimmune and prothrombotic conditions. Livedo reticularis (LR) is a cutaneous vascular pattern associated with impaired dermal arteriolar blood flow and increased vascular ri...

A. Baniel, C. Ricco, R. Dhiman et al. · 0 citations
Open access Oct 2026

Adding Tat-Beclin1 to an endurance training program promotes additive improvements in physical function in aged male mice.

Autophagy is a hallmark of aging, but it has not been exclusively targeted to attenuate aging-related physical dysfunction. Here, we combined Tat-Beclin1 and endurance training to determine its effect on physical function domains in aged male mice. Mice were randomly divided into Control (N = 5), Tat-Beclin1 (TB, 15 mg...

T. Tchen, Shakibur Rahman, T. Ghiarone et al. · 0 citations
Open access Jul 2026

HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors 2258016

HLA-Shuttle restores antigen presentation in immunologically cold tumor cells, facilitating identification of TAAs with favorable therapeutic potential and identifying multiple novel tumor associated antigens (TAAs) from both known and novel cancer immunotherapy targets.

Daniel Hwang, Molly C. Erdman, Santosh Adhikari et al. · 0 citations

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