The Multimodal Pretraining Framework CarHE Predicts Spatial Transcriptomics in Tumors from Routine Pathology Images.
CarHE (contrastive alignment of gene expression for hematoxylin and eosin images), a multimodal pretraining framework that infers high-dimensional spatial transcriptomic profiles from routine H&E-stained slides, provides a cost-effective and scalable framework for H&E-based spatial inference, supporting further validat...