Inflammatory signals are broadly conserved, yet how tissue context converts them into programs of recovery or maladaptive repair remains unclear. Using kidney injury as a model of inflammation-to-repair transitions, we identify an injury-induced proximal-tubule complement program in which cell-intrinsic complement prot...
Tilo Freiwald, Daniel Chauss, Md Tajmul et al.· bioRxiv· 0 citations
A BACH2—STAT5 transcriptional module is identified that is essential for C3 expression in activated CD4+ T cells and redirects C3 output toward a short, intracellular proteoform with noncanonical complement activity.
Jorge Trujillo, D. Chauss, Luopin Wang et al.· Journal of Immunology· 0 citations
It is shown that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages the transcription factor Sp1 in human CD4 T cells to dynamically modulate Sp1-DNA interactions, defining a human-specific transcriptional mechanism linking complement signaling to metabolic adaptation, apoptosis regulation, and antiviral defe...
A systematic catalog of eRNAs in human adaptive immune cells is defined and a distal transcribed enhancer is identified that fine-tunes KRAS signaling in Tfh cells to support effective vaccine responses, establishing eRNAs as noncoding regulators of T cell circuits controlling antibody production.
Dhaneshwar Kumar, S. Sahoo, B. Yan et al.· Journal of Immunology· 0 citations
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