Author

Lun-Zhi Yuan

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Open access Sep 2026

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model

This study initiated a multidimensional combination therapy of dexamethasone, heparin and the broad-spectrum viral decoy CoVR-MV at three days after infection and resulted in a potent reduction of high mortality, body weight loss, viral load, lung pathology and cytokine storm.

Ming Zhou, Xuan Liu, Jin-Xin Miao et al. · Molecular Biomedicine · 0 citations

Open access Sep 2026

An Engineered Spike Immunogen Drives Broad Protection of a Bivalent Recombinant Protein COVID-19 Vaccine in Animal Models

The continued evolution of SARS-CoV-2 has reduced the protective effectiveness of first-generation vaccines and underscores the need for broadly reactive next-generation vaccine candidates. Here, we evaluated STFKB, an alum-adjuvanted bivalent recombinant protein vaccine composed of the monomeric Spike (STFKprototype)...

Zi-Kang Wang, Jia-Hua Gao, Ru Bai et al. · Viruses · 0 citations

Aug 2026

Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia.

It is demonstrated that a rational combination of pharmacological targeting of innate and adaptive immune responses is sufficient to reduce mortality and severe illness caused by beta, delta and EG.1 variants in SARS-CoV-2 infection.

Ming Zhou, Xuan Liu, Haiqing Xiao et al. · Molecular Therapy · 0 citations