Luke S. Sheakley

Biomaterial-Activated Macrophage-T Cell Crosstalk Promotes Myofibroblastic Differentiation of Mesenchymal Stem Cells.

Biomaterials for orthopedic and dental implantation are designed to promote the timely resolution of inflammation and new bone formation while limiting the deposition of fibrotic tissue, which can cause implant failure. During the immune response to implantation, T cells at the peri-implant interface release cytokines...