Fluorescent imaging in live cells is a cornerstone of life sciences. While natural fluorescent proteins have been engineered to enhance individual features, no existing tag combines ideal properties into a single system: high brightness, reversible binding, compact size, and stability across diverse conditions. Here, w...
Yu-Da Chen, Klaus Yserentant, Kibeom Hong et al.· Cell· 0 citations
To understand neural computations, one would like to relate circuit dynamics to neuronal intrinsic excitability and connectivity. We developed tools for large-scale all-optical electrophysiology and applied them to approximately 300 layer 1 interneurons per mouse in vivo. Across two mice, targeted stimulation and volta...
Yitong Ǫi, Vicente J. Parot, Xiang Wu et al.· bioRxiv· 0 citations
Controlling protein localization through chemical biology tools is essential for mechanistic interrogations, functional perturbations, and therapeutic development. While existing tools cover a wide range of applications, no single approach simultaneously enables inducible trapping, controlled release, and visualization...
W. Beyers, Sarah E. Plutkis, Kathryn R. Butcher et al.· bioRxiv· 0 citations
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