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Author

Lukasz A. Joachimiak

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Open access Oct 2026

A minimally modified AAV9 variant (AAV9fyhr) for enhanced CNS gene delivery by intra-CSF administration

Adeno-associated virus (AAV) mediated gene therapies continue to show promise for the treatment of genetic diseases. However, delivery and safety still represent significant prohibitive barriers restricting translation of these delivery modalities to humans. We describe a novel AAV9 variant, “AAV9fyhr” or “FYHR”, ident...

Irvin T. Garza, V. Ramesh, Yu-Hui Hu et al. · 0 citations
Open access Oct 2026

Large-Scale Mutagenesis Identifies Sequence Changes That Bias Tau Toward CTE-like Aggregation

Tau amyloid fibrils adopt disease-specific structures across tauopathies, yet the sequence determinants that favor one pathological fold over another remain poorly defined. Here we combine computational saturation mutagenesis and energetic profiling, in vitro aggregation, cryo-EM and cellular seeding assays to identify...

Chad M. Dashnaw, Simran Rastogi, Nabil Morgan et al. · 0 citations

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