Lukas van den Heuvel

Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity

A human isogenic induced pluripotent stem cell–derived dopaminergic neuron (iDA) model is presented that faithfully recapitulates the diverse biochemical, morphological, and ultrastructural features of LB neuropathology and provides critical insight into how different pathways to aSyn fibrillization and the complex interaction between aSyn fibrils and membranous organelles shape the morphological diversity of LB-like inclusions.