Open access
Oct 2026
Macrophage-specific LAMTOR2 deletion disrupts systemic iron homeostasis in mice.
At the center of iron homeostasis, macrophages play a crucial role by phagocytosing senescent erythrocytes while nursing erythrocyte progenitors. A major route of cellular iron acquisition occurs via transferrin receptor 1 (TFR1)-mediated endocytosis of transferrin-bound iron, a process that critically depends on endos...
Laura Homs Pérez, I. Portnaia, Markus Seifert et al.
· Haematologica · 0 citations