Luiza Caroline Oliveira Rocha

Three-dimensional in vitro models for assessing temozolomide sensitivity in glioblastoma

IDH-wildtype glioblastoma, or glioblastoma multiforme (GBM), is the most aggressive primary malignancy of the central nervous system. It is characterized by marked invasiveness, intratumoral heterogeneity, and high recurrence rates, largely driven by intrinsic and acquired resistance to standard temozolomide (TMZ) th...