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Luiz Costa

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Review Open access Sep 2026

Neurocognitive links between anomic aphasia, autistic identity, and persistent behavior: An integrative review of language, executive function, and self-regulation in Autism Spectrum Disorder

This study aims to present an integrative review and propose an interpretive matrix — grounded in the authors’ original clinical observations — addressing the intersection between Autism Spectrum Disorder (ASD), anomic aphasia, identity development, and persistent behavioral patterns, while examining the underlying bio...

Giovanna Azevedo Rodrigues, Fernando Martins Castanheira, Luiz Costa et al. · 0 citations
Review Open access Sep 2026

From Form to Function: Cognitive Psychiatry, Philosophy of Mathematics, and the Psychogenesis of Number

The objective of this article is to propose an interdisciplinary interpretive matrix that articulates philosophy of mathematics, cognitive psychiatry, and recent neuroscientific discoveries (2021-2026) on embodied numerical cognition, in order to bridge the gap between the formal validity of mathematics and its cogniti...

Giovanna Azevedo Rodrigues, Fernando Martins Castanheira, Luiz Costa et al. · 0 citations
Open access Sep 2026

Cognitive psychiatry of mediumship: A genetic, neuroconnectomic, interhemispheric, and psychofunctional hypothesis of brain organization in mediums

Mediumship is a complex human phenomenon that can be investigated by cognitive psychiatry and consciousness neuroscience without theological assumptions or psychopathological reductionism. This study aimed to formulate and theoretically substantiate a neuroconnectomic, genetic, and psychofunctional hypothesis of medium...

João Acyr Chueiry, Giovanna Azevedo Rodrigues, Luiz Costa et al. · 0 citations
Review Open access Sep 2026

Haloperidol as a Novel Augmentation Strategy in Treatment-Resistant Depression: A Clinical Practice Perspective with Case Series

Treatment-resistant depression (TRD) remains a major clinical challenge when adequate antidepressant trials fail to achieve remission. This clinical practice perspective examines low-dose haloperidol as a potential augmentation strategy in carefully selected, treatment-refractory affective presentations. The manuscript...

Giovanna Azevedo Rodrigues, Fernando Martins Castanheira, Luiz Costa et al. · 0 citations
Review Open access Aug 2026

The General Psychiatric Syndrome as a Transdiagnostic Hypothesis: A Critical Appraisal of Evidence, Interpretation and Clinical Reach

Persistent comorbidity, diagnostic instability and the scarcity of disorder-specific causes have encouraged the proposal that a single superordinate dimension underlies liability to all common mental disorders. This proposition, expressed empirically as the general factor of psychopathology and framed conceptually as a...

Luiz Costa, Fernando Martins Castanheira, Giovanna Azevedo Rodrigues et al. · 1 citation

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