Open access
Oct 2026
Good vibes keep worries at bay: a prefrontal-hypothalamic pathway engages positive affect to mitigate fear
This study shows that key cortico-hypothalamic projections manage extinction retrieval and positive affect to promote fear extinction, and discovered that SIRT1-expressing mPFC-SuM extinction-recruited projections control extinction relapse vulnerability.
Quan-Son Eric Le, Luis E. Rosas-Vidal
· Journal of Clinical Investig... · 0 citations