Luiggi Kevin Virgino Brandão

Chronic kidney disease and cognitive decline: choroid plexus remodeling, glymphatic dysfunction, and alzheimer biomarker interpretation

Cognitive impairment is common in chronic kidney disease (CKD), yet vascular, uremic, dialysis-related, and neurodegenerative mechanisms are often considered separately. We propose an integrated kidney–brain tissue-environment framework to support neurological interpretation of cognitive, imaging, and biomarker finding...

CKDu and Heat Stress Nephropathy Across Eras: Regional Heterogeneity, Occupational Evidence, and Prevention in a Warming World.

Zilebesiran in Hypertension: Reversibility, Acute Illness, and Therapeutic Flexibility.

The concern is not that harm has been demonstrated, but that prolonged angiotensinogen silencing may reduce short-term therapeutic flexibility during sepsis, perioperative stress, acute heart failure, marked volume depletion, or hyperkalemia-settings in which clinicians often rely on temporary adjustment of oral renin-...