The rat is the primary animal model for preclinical research on spinal cord injury (SCI)-induced neurogenic lower urinary tract dysfunction (nLUTD). Owing to its anatomical and functional similarity to humans, rats closely recapitulate key pathological consequences of SCI. However, a crucial translational gap remains:...
Martha Georgina Brandtner, E. Beyerer, Michael Kleindorfer et al.· Journal of Visualized Experi...· 0 citations
The unfavorable functional trends and intensified inflammatory and injury-related pathways suggested adverse effects rather than therapeutic benefit under the conditions studied may indicate the importance of injury model-specific mechanisms and of dose and timing when developing anti-inflammatory strategies for SCI-in...
Michael Kleindorfer, K. Roider, K. Monastyrskaia et al.· International Neurourology J...· 0 citations
Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is characterized by progressive synaptic and neuronal loss, amyloid-β deposition, hyperphosphorylated tau accumulation, and chronic neuroinflammation, traditionally attributed primarily to the innate immune system. Increasing evidence,...
Marco Zattoni, Ludwig Aigner· Molecular Neurodegeneration· 0 citations
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