Author

L. P. da Silva

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Review Open access Oct 2026

Modeling cancer cachexia: from preclinical platforms to biosensing innovations.

Cancer cachexia is a multifactorial and progressive syndrome characterized by the not fully reversible loss of skeletal muscle and adipose tissue, which significantly impairs treatment tolerance, quality of life, and patient survival. Despite its high clinical burden, cachexia remains underdiagnosed and undertreated, l...

Rita Lima-Sousa, Aike Sijtsma, Lucília Pereira da Silva et al. · Seminars in Cancer Biology · 0 citations

Open access Aug 2026

Injectable gellan gum hydrogel systems with Doxorubicin and melanin nanoparticles for chemo-photothermal osteosarcoma treatment.

Osteosarcoma remains one of the most aggressive bone malignancies, with limited advances in effective therapies. Herein, we developed injectable, in situ gel-forming hydrogels based on gellan gum (GG, 0.75% and 1.25% w/v), naturally extracted melanin nanoparticles (MNPs, 0-500 μg/mL), and Doxorubicin (Dox, 20 μg/mL) fo...

Mariana Caldas, L. P. da Silva, I. Kwon et al. · Biomaterials Advances · 0 citations