Lucile Plumet

Training a phage to expand its host range: directed evolution against Staphylococcus aureus from diabetic foot infections

Both the potential and the limitations of phage training to expand therapeutic coverage are demonstrated and the need to integrate evolutionary approaches with physiologically relevant models to optimize phage therapy for chronic infections, such as DFIs is emphasized.

Unraveling Resistance and Thresholds in Phage Therapy Using In Vitro Staphylococcus aureus experiments and Pharmacokinetic/Pharmacodynamic Models.