SAMD9/9L Innate Immunity: Antiviral Mechanisms and Evolutionary Trade-Offs of Multidomain Proteins.
Sterile alpha motif domain-containing 9 and 9-like (SAMD9/9L) are large multidomain proteins with antiviral innate immune and cellular homeostasis functions. Initially characterized as tumor suppressors, they are now also recognized as antiviral restriction factors against diverse viruses, including poxviruses, lentivi...