Lucía González-Pico

Bridging E3 Ligase Binding and Targeted Degradation Through Fluorescence Polarization

Despite the rapid expansion of targeted protein degradation (TPD), early characterization of PROTACs and molecular glues still relies predominantly on cellular degradation assays, making it difficult to determine whether poor degradation results from suboptimal E3 ligase engagement or from subsequent steps in the degra...