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Open access Sep 2026

White Matter Slow-4 fALFF as a Complementary Marker in the Multimodal Alzheimer’s Disease Biomarker Landscape

INTRODUCTION White matter (WM) functional activity, quantified as slow-4 fractional amplitude of low-frequency fluctuations (fALFF; 0.027–0.073 Hz), may reflect Alzheimer’s disease (AD) pathology, but its utility relative to established structural imaging markers remains poorly characterized. METHODS We analyzed 369 AD...

Ya-Li Huang, A. Toga, Lu Zhao · 0 citations

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