Open access
Aug 2026
Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation
In vivo experiments demonstrated that 6PPD-Q exposure significantly exacerbated DSS-induced colonic shortening, macroscopic lesions, and histopathological damage, and provided an integrative mechanistic framework for investigating the potential intestinal effects of 6PPD-Q under inflammatory conditions.
Jing-Yi Li, Xi-Zhuang Gao, Ye-Min Xu et al.
· Frontiers in Immunology · 0 citations