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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Luqing Shang

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Open access Oct 2026

Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide

Abstract Nucleoside/nucleotide analogs (NAs) typically interfere with substrate selection and catalysis steps of polymerase nucleotide addition cycle (NAC), thereby affecting polymerase catalytic efficiency. In contrast, their interference with post-chemistry translocation is rarely considered in rational design, partl...

Rui Li, Qiang Shao, Mei-Hua Wang et al. · 0 citations
Open access Jul 2026

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

It is demonstrated that targeted protein degradation can effectively induce the degradation of 3CPro in picornaviruses, supporting the development of resistance‐resistant, broad‐spectrum antiviral agents and highlighting their potential to address evolving viral threats.

Weilong Deng, Jun-Yu Chen, Yingyue Pang et al. · 0 citations

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