Lu-Lu Chen

Trimethylamine N-oxide drives cardiac hypertrophy through H3K27ac-mediated enhancer activation of ketohexokinase.

Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, promotes cardiac hypertrophy, yet the molecular mechanisms linking microbial metabolism to cardiac gene expression remain incompletely defined. Ketohexokinase (KHK), the rate-limiting enzyme of fructose catabolism, is implicated in cardiac pathology, b...