Sepsis is a life-threatening syndrome defined by infection-triggered dysregulation of the host response, and its persistently high mortality and marked clinical heterogeneity remain major barriers to early risk stratification and individualized management. While the gut is increasingly recognized as a key modulator of...
Shi-Yang Zhang, Li-Zhou Song, Yan Liao et al.· Ageing Research Reviews· 0 citations
Innate immune responses must be tightly controlled to maintain immuno-homeostasis. However, the regulatory mechanisms underlying the activation and early stages of the innate immune response remain poorly defined. Here, we found the soluble C-type lectin Clec18a is up-regulated in multiple inflammatory diseases, includ...
Zheng-Yu Jiang, Lu-Long Bo, Na Li et al.· bioRxiv· 0 citations
Ischemia-reperfusion injury (IRI) contributes to the pathogenesis of major diseases, including acute kidney injury, stroke, and myocardial infarction. Multiple forms of cell death, including apoptosis, necroptosis, pyroptosis, autophagy, and ferroptosis, are key contributors to IRI. The interplay among these cell-death...
Chuan-Gang Yao, Qi Wu, Zhi Wang et al.· Biomarker Research· 0 citations
This exploratory study provides a preliminary ED50 estimate for tegileridine in immediate post-LCRS analgesia within a multimodal regimen, with a favorable short-term safety profile, however, the wide CI limits these findings.
Minna Guo, Tong Wang, Shuchi Lin et al.· Drug Design, Development and...· 0 citations
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