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Aug 2026

Polyphenol-engineered selenium nanocatalysts enable neuroprotective glioblastoma chemoimmunotherapy via nose-to-brain delivery.

Glioblastoma therapy is severely limited by poor blood-brain barrier (BBB) penetration and systemic toxicity of chemotherapeutics. Here, we engineered polyphenol-stabilized selenium nanoparticles (nGPSe NPs, <60 nm) via spatial confinement synthesis as a redox-dual nanocatalytic carrier for afatinib (AFA). These AFA@nG...

Shunming Hong, Rong Hu, Qing-Bin Nie et al. · 0 citations
Open access Sep 2026

A logic-gated nanoplatform spatiotemporally orchestrates immunometabolic reprogramming and osteogenesis for diabetic periodontal regeneration

Achieving periodontal regeneration in diabetic periodontitis (DPD) is hindered by a self-perpetuating vicious cycle of excessive oxidative stress and adaptive immune dysfunction. Here, using clinical samples, multi-omics profiling, and DPD rat model, we identified an association between oxidative stress and CD4+ T cell...

Yu-Jun Jiang, Shu-Yun Liu, Xiao-Lin Li et al. · 0 citations

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