Open access
Sep 2026
IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis activity in healthy participants.
Tregs play an essential role in immune tolerance, and Treg-promoting therapies are in development for the treatment of many inflammatory disorders. Interleukin-2 (IL-2)-based therapies increase Treg frequency, but little is known about impacts on Treg heterogeneity and function. We extended analyses of an IL-2 mutein (...
Laura A. Cooney, M. Fahning, Liliane Khoryati et al.
· JCI Insight · 0 citations