Magnesium is an essential cofactor in numerous enzymatic reactions regulating neuronal excitability, neurotransmission, and stress response. Deficiency has been linked to affective dysregulation through altered N-methyl-D-aspartate (NMDA) and γ-aminobutyric acid (GABA) signaling, impaired neuroplasticity, and activatio...
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Food Production, Processing...· 0 citations
Lithium exposure was consistently associated with reduced dementia risk, and the magnitude, consistency, and biological plausibility support lithium as a promising candidate for dementia prevention research.
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Journal of Alzheimer's Disea...· 0 citations
Eotional reliance on AI represents an emerging clinical phenomenon with addiction-like features requiring specific diagnostic frameworks, evidence-based interventions, and ethical design guidelines and future research should prioritize longitudinal studies examining developmental impacts and neurobiological investigati...
M. Lastretti, M. Manchia, Matteo Fraschini et al.· Psychiatry International· 0 citations
Gut microbiota dysbiosis represents a biologically plausible mediator of depression pathophysiology, with a recurrent dysbiotic pattern, characterised by depletion of butyrate-producing taxa and enrichment of pro-inflammatory genera, showing emerging diagnostic and therapeutic potential.
Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al.· Swiss Archives of Neurology,...· 0 citations
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