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Longfei Jia

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Open access Sep 2025

Profiling of terminating ribosomes reveals translational control at stop codons

A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, established as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-specific translational control.

Longfei Jia, Yuanhui Mao, Saori Uematsu et al. · 4 citations
Open access Jul 2026

Profiling of terminating ribosomes reveals translational control at stop codons

A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, suggesting termination pausing as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-specific translational control.

Longfei Jia, Yuanhui Mao, Saori Uematsu et al. · 1 citation
Open access Jul 2026

The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos.

Findings suggest that specific maternal RBPs may act as repressors that require precise degradation post-fertilization to relieve translational repression and ensure successful MZT.

Pinhua Wang, Siqi Wang, Haojie Yin et al. · 0 citations

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