A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, established as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-specific translational control.
A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, suggesting termination pausing as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-specific translational control.
Findings suggest that specific maternal RBPs may act as repressors that require precise degradation post-fertilization to relieve translational repression and ensure successful MZT.
Pinhua Wang, Siqi Wang, Haojie Yin et al.· Cellular and Molecular Life...· 0 citations
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