PBK drives pulmonary fibrosis via activating p53/ACVR1C/Smad-mediated epithelial-mesenchymal transition.
Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options. PDZ-binding kinase (PBK), also known as T-cell-originated protein kinase activated by lymphokines (TOPK), is implicated in cancer progression and inflammation, yet its role in fibrosis remains unexplored. This...