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Long-Xian Li

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Open access Jul 2026

Computational Redesign of Aspartase from Escherichia coli and Its Catalytic Synthesis of β-Alanine

Aspartase from Escherichia coli (AspA) catalyzes the direct conversion of acrylic acid to β-alanine; however, its substrate specificity and low catalytic efficiency limit its broader application. We engineered an AspA mutant capable of efficiently catalyzing the amination of acrylic acid for β-alanine synthesis, using...

Long-Xian Li, Bao-Di Ma, Yi Xu · Catalysts · 0 citations

Preprint Aug 2026

An Entropy-based Coefficient of Determination with Adjustment of Optimization Bias

Classical likelihood-ratio tests and $\Delta$AIC exacerbate the statistical significance crisis by scaling with sample size, often flagging negligible improvements as highly significant. While causal estimands like the average treatment effect (ATE) quantify practical magnitude, their reliance on the expectation operat...

Long-Xian Li · 0 citations