Author

Longkun Gao

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Open access Aug 2026

Computer-aided drug screening of anti-Neobenedenia melleni drugs based on annexin B1 in farmed pearl grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus ♂)

In vivo validation of eleven compounds identified abamectin (Aba) as the most effective anti-Neobenedenia agent, achieving complete parasite elimination at 0.16 mg/L, corresponding to a therapeutic index of approximately 7.7.

Long-Kun Gao, Wei Luo, Yan-Ru Guo et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

In Vivo Screening for a Promising Antiparasitic Agent Against Neobenedenia melleni in Epinephelus fuscoguttatus♀ × E. lanceolatus♂ and Identification of Its Potential Target

Findings highlight compound D as a promising lead candidate for short-bath therapy against N. melleni and suggest that cytoskeletal disruption through β-tubulin interaction represents a plausible mechanism of action.

Long-Kun Gao, Guang-Shuo Wang, Jun-Tao Xu et al. · bioRxiv · 0 citations