Open access
Sep 2026
A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges
The design and preclinical evaluation of SV suggest that heterodimeric RBD architectures incorporating antigenically divergent variants may represent a generalizable platform for countering viral immune evasion, with implications for future SARS-CoV-2 variants and other rapidly evolving viral pathogens.
Jia-Li Xu, Rui Peng, Long-Hai Yuan et al.
· Molecular Biomedicine · 0 citations