Open access
Aug 2026
Harnessing the E3 Ligase KLHL12 for Tumor-Selective Protein Degradation.
KLHL12 is identified as a potentially tumor-selective E3 ligase and the development of the first-in-class KLHL12-recruiting PROTACs are reported, which established KLHL12 as a promising tumor‑selective E3 ligase and provided a KLHL12-recruiting PROTAC platform for cancer therapy.
Shicheng Xu, Xian Zhang, Shun-Bo Hu et al.
· Angewandte Chemie · 0 citations