Human sperm and oocytes carry highly distinct DNA methylation landscapes, yet parental DNA methylation ultimately converges to a largely equivalent state, raising the question of when and how the allelic DNA methylome is reprogrammed toward convergence. Here, we present an integrated allelic analysis of DNA methylation...
Fan-Qing Xu, Qian Liu, Zheng-Rong Du et al.· Genome Research· 0 citations
Abstract Background Oocyte cryopreservation is widely used in assisted reproductive technology, but its effects on embryonic development remain a concern. This study aimed to determine whether oocyte cryopreservation induces transcriptional alterations at the early cleavage and blastocyst stages. Methods We performed s...
Yi-Xin Ren, Qing-Yang Zhang, Fan-Qing Xu et al.· Clinical and Translational M...· 0 citations
A comprehensive, non-integrating method for generating aneuploid human iPSCs from primary AFCs using episomal plasmid electroporation that yields aneuploid iPSC lines suitable for disease modeling, drug screening, and studies of chromosome biology.
Zi-Fan Song, Jing Wang, Peng Yuan et al.· Journal of Visualized Experi...· 0 citations
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