Next-Generation Sequencing Clonality Assays: Clinical Validation for Minimal Residual Disease Monitoring in Multiple Myeloma.
Minimal residual disease (MRD) detection is crucial for managing lymphoid malignancies. This study introduces OriMIRACLE LTM, a novel next-generation sequencing (NGS)-based B-cell receptor (BCR) and T-cell receptor (TCR) clonality assay for MRD detection. We validated the assay using cell lines and clinical samples, in...